副結核分支桿菌基因多型性之研究

Mycobacterium avium subspecies paratuberculosis (MAP) causes paratuberculosis or Johne’s disease, an intestinal granulomatous infection. The disease spreads by ingestion of MAP from the contaminated environment. Lesions occur in the small intestine and the draining mesenteric lymph nodes which are responsible for a protein leak and a protein malabsorption syndrome. The genotyping methods applied to MAP include IS900- or IS1311-RFLP (restriction fragment length polymorphism), SSR (short sequence